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Enantioselective cleavage of cyclobutanols through Ir‐catalyzed C‐C bond activation: Mechanistic and synthetic aspects

F. Ratsch, J. P. Strache, W. Schlundt, J.-M. Neudörfl, A. Adler, S. Aziz, B. Goldfuss, H.-G. Schmalz, Chem. Eur. J.10.1002/chem.202004843

Abstract

The Ir‐catalyzed conversion of prochiral tert‐cyclo­butanols to β‐methyl‐substituted ketones proceeds under comparably mild conditions in toluene (45–110°C) and is particularly suited for the enantio­selective desymmetrization of β‐oxy‐substituted substrates to give products with a quaternary chirality center with up to 95% ee using DTBM‐SegPhos as a chiral ligand. Deuteration experi­ments and kinetic isotope effect measurements revealed major mechanistic differences to related Rh(I)‐catalyzed transformations. Supported by DFT calculations we propose the initial formation of an Ir(III) hydride intermediate which then undergoes a β‐C elimination (C‐C bond activation) prior to reductive C‐H elimination. The computational model also allows the prediction of the stereochemical outcome. The Ir‐catalyzed cyclobutanol cleavage is broadly applicable but fails for substrates bearing strongly coordinating groups. The method is of particular value for the stereo‐controlled synthesis of substituted chromanes related to the tocopherols and other natural products.


Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells

M. Barone, M. Müller, S. Chiha, J. Ren, D. Albat, A. Soicke, S. Dohmen, M. Klein, J. Bruns, M. van Dinther, R. Opitz, P. Lindemann, M. Beerbaum, K. Motzny, Y. Roske, P. Schmieder, R. Volkmer, M. Nazaré, U. Heinemann, H. Oschkinat, P. ten Dijke, H.-G-Schmalz, R. Kühne, PNAS 2020, 117(47), 29684, 10.1073/pnas.2007213117

Abstract

Battling metastasis through inhibition of cell motility is considered a promising approach to support cancer therapies. In this context, Ena/VASP-depending signaling pathways, in particular interactions with their EVH1 domains, are promising targets for pharmaceutical intervention. However, protein–protein interactions involving proline-rich segments are notoriously difficult to address by small molecules. Hence, structure-based design efforts in combination with the chemical synthesis of additional molecular entities are required. Building on a previously developed nonpeptidic micromolar inhibitor, we determined 22 crystal structures of ENAH EVH1 in complex with inhibitors and rationally extended our library of conformationally defined proline-derived modules (ProMs) to succeed in developing a nanomolar inhibitor (Kd=120 nM, MW=734). In contrast to the previous inhibitor, the optimized compounds reduced extravasation of invasive breast cancer cells in a zebrafish model. This study represents an example of successful, structure-guided development of low molecular weight inhibitors specifically and selectively addressing a proline-rich sequence-recognizing domain that is characterized by a shallow epitope lacking defined binding pockets. The evolved high-affinity inhibitor may now serve as a tool in validating the basic therapeutic concept, i.e., the suppression of cancer metastasis by inhibiting a crucial protein–protein interaction involved in actin filament processing and cell migration.


Colchicine Alkaloids and Synthetic Analogues: Current Progress and Perspectives

I. A. Gracheva, E. S. Shchegravina, H.-G. Schmalz, I. P. Beletskaya, A. Y. FedorovJ. Med. Chem. 202063(19), 10618, 10.1021/acs.jmedchem.0c00222

Abstract

Colchicine, the main alkaloid of Colchicum autumnale, is one of the most famous natural molecules. Although colchicine belongs to the oldest drugs (in use since 1500 BC), its pharmacological potential as a lead structure is not yet fully exploited. This review is devoted to the synthesis and structure–activity relationships (SAR) of colchicine alkaloids and their analogues with modified A, B, and C rings, as well as hybrid compounds derived from colchicinoids including prodrugs, conjugates, and delivery systems. The systematization of a vast amount of information presented to date will create a paradigm for future studies of colchicinoids for neoplastic and various other diseases.


Synthesis of the 8,19-Epoxysteroid Eurysterol A

Ö. Taspinar, T. Wilczek, J. Erver, M. Breugst, J.-M. Neudoerfl, H.-G. Schmalz, Chem. Eur. J. 2020, 26(19), 4256, 10.1002/chem.202000585

Abstract

We report the first chem. synthesis of eurysterol A (I), a cytotoxic and antifungal marine steroidal sulfate with a unique C8- C19 oxy-bridged cholestane skeleton. After C19 hydroxy lation of cholesteryl acetate, used as an inexpensive com. starting material, the challenging oxidative functionalization of ring B was achieved by two different routes to set up a 5α- hydroxy-7-en-6-one moiety. As a key step, an intramol. oxa-Michael addition was exploited to close the oxy-bridge (8β,19-epoxy unit). DFT calculations show this reversible transformation being exergonic by about - 30 kJ mol . Along the optimized (scalable) synthetic sequence, the target natural product was obtained in only 11 steps in 5 % overall yield. In addition, an access to (isomeric) 7β,19-epoxy steroids with a previously unknown pentacyclic ring system was discovered.


Pd-catalyzed asymmetric N-allylation of amino acid esters with exceptional levels of catalyst control: Stereo-divergent synthesis of ProM-15 and related bicyclic dipeptide mimetics

S. Dohmen, M. Reiher, D. Albat, S. Akyol, M. Barone, J.-M. Neudoerfl, R. Kuehne, H.-G. Schmalz, Chem. Eur. J. 2020, 26(14), 3049, 10.1002/chem.202000307

Abstract

A general and powerful method for the stereo‐controlled Pd‐catalyzed N‐allylation of amino acid esters is reported, as a previously largely unsolved synthetic challenge. Employing a new class of tartaric acid‐derived C2‐symmetric chiral diphosphane ligands the developed asymmetric amination protocol allows the conversion of various amino acid esters to the N‐allylated products with highest levels of enantio‐ or diastereoselectivity in a fully catalyst‐controlled fashion and predictable configuration. Remarkably, the in situ generated catalysts also exhibit outstanding levels of activity (ligand acceleration). The usefulness of the method was demonstrated in the stereo‐divergent synthesis of a set of new conformationally defined dipeptide mimetics, which represent new modular building blocks for the development of peptide‐inspired bioactive compounds.


Triple‐Helix‐Stabilizing Effects in Collagen Model Peptides Containing PPII‐Helix‐Preorganized Diproline Modules

A. Maaßen, J. M. Gebauer, E. T. Abraham, I. Grimm, J.‐M. Neudörfl, R. Kühne, I. Neundorf, U. Baumann, H.‐G. Schmalz, Angew. Chem. Int. Ed. 2020, 59(14), 5747, 10.1002/anie.201914101

Abstract

Collagen model peptides (CMPs) serve as tools for understanding stability and function of the collagen triple helix and have a potential for biomedical applications. In the past, interstrand cross‐linking or conformational preconditioning of proline units through stereoelectronic effects have been utilized in the design of stabilized CMPs. To further study the effects determining collagen triple helix stability we investigated a series of CMPs containing synthetic diproline‐mimicking modules (ProMs), which were preorganized in a PPII‐helix‐type conformation by a functionalizable intrastrand C2 bridge. Results of CD‐based denaturation studies were correlated with calculated (DFT) conformational preferences of the ProM units, revealing that the relative helix stability is mainly governed by an interplay of main‐chain preorganization, ring‐flip preference, adaptability, and steric effects. Triple helix integrity was proven by crystal structure analysis and binding to HSP47.

 

Publications

[1] Design and Synthesis of New Protease-Triggered CO-Releasing Peptide-Metal-Complex Conjugates, N. S. Sitnikov, Y. B. Malysheva, A. Y. Fedorov, H. G. Schmalz, Eur. J. Org. Chem., 2019, 2019 (40), 6830. 10.1002/ejoc.201901206

[2] A Facile Synthetic Approach to Nonracemic Substituted Pyrrolo-allocolchicinoids Starting from Natural Colchicine, E. S. Shchegravina, E. V. Svirshchevskaya, H. G. Schmalz, A. Y. Fedorov, Synthesis, 2019, 51 (7), 1611. 10.1055/s-0037-1610673

[3] The Science Forum in Aachen: Joyful Expectations, H. G. Schmalz, CHEMKON, 2019, 26 (5), 177. 10.1002/ckon.201900048

[4] Total Synthesis of alpha-Tocopherol through Enantioselective Iridium-Catalyzed Fragmentation of a Spiro-Cyclobutanol Intermediate, F. Ratsch, W. Schlundt, D. Albat, A. Zimmer, J. M. Neudorfl, T. Netscher, H. G. Schmalz, Chem. Eur. J., 2019, 25 (19), 4941. 10.1002/chem.201900564

[5] Regeneration of ergothioneine after reaction with singlet oxygen, M. Oumari, B. Goldfuss, C. Stoffels, H. G. Schmalz, D. Grundemann, Free Radical Biol. Med., 2019, 134, 508. 10.1016/j.freeradbiomed.2019.01.043

[6] Inhibition of CPAP-tubulin interaction prevents proliferation of centrosome-amplified cancer cells, A. Mariappan, K. Soni, K. Schorpp, F. Zhao, A. Minakar, X. D. Zheng, S. Mandad, I. Macheleidt, A. Ramani, T. Kubelka, M. Dawidowski, K. Golfmann, A. Wason, C. H. Yang, J. Simons, H. G. Schmalz, A. A. Hyman, R. Aneja, R. Ullrich, H. Urlaub, M. Odenthal, R. Buttner, H. T. Li, M. Sattler, K. Hadian, J. Gopalakrishnan, EMBO J., 2019, 38 (2). 10.15252/embj.201899876

[7] Comment on Enantioselective total synthesis of (-)-colchicine, (+)-demecolcinone and metacolchicine: determination of the absolute configurations of the latter two alkaloids by B. Chen, X. Liu, Y.-J. Hu, D.-M. Zhang, L. Deng, J. Lu, L. Min, W.-C. Ye and C.-C. Li, Chem. Sci., 2017, 8, 4961-4966, R. W. Hoffmann, H. G. Schmalz, U. Koert, G. K. Pierens, Chem. Sci., 2019, 10 (3), 943. 10.1039/c8sc90247j

[8] A Stereoselective Synthesis of the ACE Inhibitor Trandolapril, S. Chiha, M. Spilles, J. M. Neudorfl, H. G. Schmalz, Synlett, 2019, 30 (7), 813. 10.1055/s-0037-1612306

[9] A synthetic derivative of houttuynoid B prevents cell entry of Zika virus, M. Basic, F. Elgner, D. Bender, C. Sabino, M. L. Herrlein, H. Roth, M. Glitscher, A. Fath, T. Kerl, H. G. Schmalz, E. Hildt, Antiviral Res., 2019, 172. 10.1016/j.antiviral.2019.104644

[10] Hydrogen Peroxide Sensors Based on Fluorescence Quenching of the 2-Aminobenzimidazole Fluorophore, M. Atar, O. Taspinar, S. Hanft, B. Goldfuss, H. G. Schmalz, A. G. Griesbeck, J. Org. Chem., 2019, 84 (24), 15972. 10.1021/acs.joc.9b02262

[11] Synthetic Indolactam V Analogues as Inhibitors of PAR2-Induced Calcium Mobilization in Triple-Negative Breast Cancer Cells, J. Stein, S. Stahn, J. M. Neudorfl, J. Sperlich, H. G. Schmalz, N. Teusch, ChemMedChem, 2018, 13 (2), 147. 10.1002/cmdc.201700640

[12] A bit of Pride may be, H. G. Schmalz, CHEMKON, 2018, 25 (1), 5. 10.1002/ckon.201880131

[13] An Atom-Economic and Stereospecific Access to Trisubstituted Olefins through Enyne Cross Metathesis Followed by 1,4-Hydrogenation, F. Ratsch, H. G. Schmalz, Synlett, 2018, 29 (6), 785. 10.1055/s-0036-1591528

[14] Chiral Phosphine-Phosphite Ligands in Asymmetric Gold Catalysis: Highly Enantioselective Synthesis of Furo 3,4-d -Tetrahydropyridazine Derivatives through 3+3 -Cycloaddition, Q. W. Du, J. M. Neudorfl, H. G. Schmalz, Chem. Eur. J., 2018, 24 (10), 2379. 10.1002/chem.201800042

[15] Design and Synthesis of Building Blocks for PPII-Helix Secondary-Structure Mimetics: A Stereoselective Entry to 4-Substituted 5-Vinylprolines, S. Chiha, A. Soicke, M. Barone, M. Muller, J. Bruns, R. Opitz, J. M. Neudorfl, R. Kuhne, H. G. Schmalz, Eur. J. Org. Chem., 2018, 2018 (4), 455. 10.1002/ejoc.201701584

[16] Ergothioneine stands out from hercynine in the reaction with singlet oxygen: Resistance to glutathione and TRIS in the generation of specific products indicates high reactivity, C. Stoffels, M. Oumari, A. Perrou, A. Termath, W. Schlundt, H. G. Schmalz, M. Schafer, V. Wewer, S. Metzger, E. Schomig, D. Grundemann, Free Radical Biol. Med., 2017, 113, 385. 10.1016/j.freeradbiomed.2017.10.372

[17] Synthesis and biological evaluation of novel non-racemic indole-containing allocolchicinoids, E. S. Shchegravina, A. A. Maleev, S. K. Ignatov, I. A. Gracheva, A. Stein, H. G. Schmalz, A. E. Gavryushin, A. A. Zubareva, E. V. Svirshchevskaya, A. Y. Fedorov, Eur. J. Med. Chem., 2017, 141, 51. 10.1016/j.ejmech.2017.09.055

[18] Chemistry Teaching in the Post-Factual Age, H. G. Schmalz, CHEMKON, 2017, 24 (1), 5. 10.1002/ckon.201710292

[19] Tandem Hydroalumination/Cu-Catalyzed Asymmetric Vinyl Metalation as a New Access to Enantioenriched Vinylcyclopropane Derivatives, D. S. Muller, V. Werner, S. Akyol, H. G. Schmalz, I. Marek, Org. Lett., 2017, 19 (15), 3970. 10.1021/acs.orglett.7b01661

[20] Synthesis and cytostatic properties of polyfunctionalized furanoallocolchicinoids, I. A. Gracheva, I. V. Voitovich, V. I. Faerman, N. S. Sitnikov, E. V. Myrsikova, H. G. Schmalz, E. V. Svirshevskaya, A. Y. Fedorov, Eur. J. Med. Chem., 2017, 126, 432. 10.1016/j.ejmech.2016.11.020

[21] Organocatalyzed Synthesis of Oleochemical Carbonates from CO2 and Renewables, H. Buttner, J. Steinbauer, C. Wulf, M. Dindaroglu, H. G. Schmalz, T. Werner, ChemSusChem, 2017, 10 (6), 1076. 10.1002/cssc.201601163

[22] Methyl Fumarate-Derived Iron Carbonyl Complexes (FumET-CORMs) as Powerful Anti-inflammatory Agents, B. Bauer, A. L. Goderz, H. Braumuller, J. M. Neudorfl, M. Rocken, T. Wieder, H. G. Schmalz, ChemMedChem, 2017, 12 (23), 1927. 10.1002/cmdc.201700488

[23] Immune modulatory effects of methyl fumarate-derived iron carbonyl complexes, B. Bauer, A. Goderz, H. Braumuller, M. Rocken, T. Wieder, H. Schmalz, Exp. Dermatol., 2017, 26 (3), E52.

[24] CO-releasing fumarate complexes show superior anti-inflammatory effects compared to dimethyl fumarate treatment, B. Bauer, A. Goderz, H. Braumuller, M. Rocken, W. Thomas, H. Schmalz, J. Invest. Dermatol., 2017, 137 (10), S262. 10.1016/j.jid.2017.07.607

[25] New Colchicine-Derived Triazoles and Their Influence on Cytotoxicity and Microtubule Morphology, P. Thomopoulou, J. Sachs, N. Teusch, A. Mariappan, J. Gopalakrishnan, H. G. Schmalz, ACS Med. Chem. Lett., 2016, 7 (2), 188. 10.1021/acsmedchemlett.5b00418

[26] Prevention of colitis by controlled oral drug delivery of carbon monoxide, C. Steiger, K. Uchiyama, T. Takagi, K. Mizushima, Y. Higashimura, M. Gutmann, C. Hermann, S. Botov, H. G. Schmalz, Y. Naito, L. Meinel, J. Controlled Release, 2016, 239, 128. 10.1016/j.jconrel.2016.08.030

[27] Synthesis of Nonracemic Pyrrolo-allocolchicinoids Exhibiting Potent Cytotoxic Activity, E. S. Shchegravina, D. I. Knyazev, I. P. Beletskaya, E. V. Svirshchevskaya, H. G. Schmalz, A. Y. Fedorov, Eur. J. Org. Chem., 2016, 2016 (34), 5620. 10.1002/ejoc.201601069

[28] CHEMISTRY A molecular shuttle for hydrogen cyanide, H. G. Schmalz, Science, 2016, 351 (6275), 817. 10.1126/science.aaf2215

[29] Chemistry Education as a Contribution and Opportunity to social Integration, H. G. Schmalz, CHEMKON, 2016, 23 (1), 5. 10.1002/ckon.201610268

[30] Low-Pressure Cobalt-Catalyzed Enantioselective Hydrovinylation of Vinylarenes, S. Movahhed, J. Westphal, M. Dindaroglu, A. Falk, H. G. Schmalz, Chem. Eur. J., 2016, 22 (22), 7381. 10.1002/chem.201601283

[31] Total Synthesis of the Antiviral Natural Product Houttuynoid B, T. Kerl, F. Berger, H. G. Schmalz, Chem. Eur. J., 2016, 22 (9), 2935. 10.1002/chem.201505118

[32] A fast and simple LC-MS-based characterization of the flavonoid biosynthesis pathway for few seed(ling)s, B. Jaegle, M. K. Uroic, X. Holtkotte, C. Lucas, A. O. Termath, H. G. Schmalz, M. Bucher, U. Hoecker, M. Hulskamp, A. Schrader, BMC Plant Biol., 2016, 16. 10.1186/s12870-016-0880-7

[33] Synthesis of New Sulfur-Containing Derivatives of Furanoallocolchicinoids, Y. A. Gracheva, H. G. Schmalz, E. V. Svirshchevskaya, A. Y. Fedorov, Rus. J. Org. Chem., 2016, 52 (8), 1137. 10.1134/s1070428016080078

[34] Synthesis of Diverse 6-Oxa-allocolchicinoids by a Suzuki-Miyaura Coupling, Acid-Catalyzed Intramolecular Transacetalization Strategy, D. B. Yadav, L. Taleli, A. E. van der Westhuyzen, M. A. Fernandes, M. Dragoun, A. Prokop, H. G. Schmalz, C. B. de Koning, W. A. L. van Otterlo, Eur. J. Org. Chem., 2015, 2015 (23), 5167. 10.1002/ejoc.201500573

[35] Synthesis and Biological Evaluation of Furanoallocolchicinoids, Y. V. Voitovich, E. S. Shegravina, N. S. Sitnikov, V. I. Faerman, V. V. Fokin, H. G. Schmalz, S. Combes, D. Allegro, P. Barbier, I. P. Beletskaya, E. V. Svirshchevskaya, A. Y. Fedorov, J. Med. Chem., 2015, 58 (2), 692. 10.1021/jm501678w

[36] Synthesis of indole-derived allocolchicine congeners exhibiting pronounced anti-proliferative and apoptosis-inducing properties, N. S. Sitnikov, A. V. Sinzov, D. Allegro, P. Barbier, S. Combes, L. A. Onambele, A. Prokop, H. G. Schmalz, A. Y. Fedorov, MedChemComm, 2015, 6 (12), 2158. 10.1039/c5md00320b

[37] Synthesis and antitumor activity of 7-(triazol-1-yl)pyrroloallocolchicine derivatives, N. S. Sitnikov, A. V. Sintsov, E. S. Shchegravina, A. Prokop, H. G. Schmalz, V. V. Fokin, A. Y. Fedorov, Rus. Chem. Bull., 2015, 64 (6), 1362. 10.1007/s11172-015-1018-z

[38] Design, Synthesis, and Functional Evaluation of CO-Releasing Molecules Triggered by Penicillin G Amidase as a Model Protease, N. S. Sitnikov, Y. C. Li, D. F. Zhang, B. Yard, H. G. Schmalz, Angew. Chem. Int. Ed., 2015, 54 (42), 12314. 10.1002/anie.201502445

[39] Design and Stereoselective Synthesis of ProM-2: A Spirocyclic Diproline Mimetic with Polyproline Type II (PPII) Helix Conformation, C. Reuter, R. Opitz, A. Soicke, S. Dohmen, M. Barone, S. Chiha, M. T. Klein, J. M. Neudorfl, R. Kuhne, H. G. Schmalz, Chem. Eur. J., 2015, 21 (23), 8464. 10.1002/chem.201406493

[40] Organometallic nucleosides induce non-classical leukemic cell death that is mitochondrial-ROS dependent and facilitated by TCL1-oncogene burden, C. Prinz, E. Vasyutina, G. Lohmann, A. Schrader, S. Romanski, C. Hirschhauser, P. Mayer, C. Frias, C. D. Herling, M. Hallek, H. G. Schmalz, A. Prokop, D. Mougiakakos, M. Herling, Mol. Cancer, 2015, 14. 10.1186/s12943-015-0378-1

[41] A modular toolkit to inhibit proline-rich motif-mediated protein-protein interactions, R. Opitz, M. Muller, C. Reuter, M. Barone, A. Soicke, Y. Roske, K. Piotukh, P. Huy, M. Beerbaum, B. Wiesner, M. Beyermann, P. Schmieder, C. Freund, R. Volkmer, H. Oschkinat, H. G. Schmalz, R. Kuhne, PNAS, 2015, 112 (16), 5011. 10.1073/pnas.1422054112

[42] Synthesis of Chlorin-(Arylamino)quinazoline Hybrids as Models for Multifunctional Drug Development, A. V. Nyuchev, V. F. Otvagin, A. E. Gavryushin, Y. I. Romanenko, O. I. Koifman, D. V. Belykh, H. G. Schmalz, A. Y. Fedorov, Synthesis, 2015, 47 (23), 3717. 10.1055/s-0034-1378876

[43] Individual steps of the Mizoroki-Heck reaction and intrinsic reactivity of intermediate organopalladium complexes studied in the gas phase, L. Fiebig, J. Held, H. G. Schmalz, M. Schafer, Eur. J. Mass Spectrom., 2015, 21 (3), 623. 10.1255/ejms.1310

[44] Enantioselective Nickel-Catalyzed Hydrocyanation using Chiral Phosphine-Phosphite Ligands: Recent Improvements and Insights, A. Falk, A. Cavalieri, G. S. Nichol, D. Vogt, H. G. Schmalz, Adv. Synth. Cat., 2015, 357 (14-15), 3317. 10.1002/adsc.201500644

[45] Biomimetic Synthesis of Isoindolinones Related to the Marilines, D. Augner, H. G. Schmalz, Synlett, 2015, 26 (10), 1395. 10.1055/s-0034-1380700

[46] Total Synthesis of (2RS)-alpha-Tocopherol through Ni-Catalyzed 1,4-Addition to a Chromenone Intermediate, A. O. Termath, J. Velder, R. T. Stemmler, T. Netscher, W. Bonrath, H. G. Schmalz, Eur. J. Org. Chem., 2014, 2014 (16), 3337. 10.1002/ejoc.201402240

[47] Total Synthesis of (R, R, R)-alpha-Tocopherol Through Asymmetric Cu-Catalyzed 1,4-Addition, A. O. Termath, H. Sebode, W. Schlundt, R. T. Stemmler, T. Netscher, W. Bonrath, H. G. Schmalz, Chem. Eur. J., 2014, 20 (38), 12051. 10.1002/chem.201404379

[48] Different design of enzyme-triggered CO-releasing molecules (ET-CORMs) reveals quantitative differences in biological activities in terms of toxicity and inflammation, E. Stamellou, D. Storz, S. Botov, E. Ntasis, J. Wedel, S. Sollazzo, B. K. Kramer, W. van Son, M. Seelen, H. G. Schmalz, A. Schmidt, M. Hafner, B. A. Yard, Redox Biol., 2014, 2, 739. 10.1016/j.redox.2014.06.002

[49] Stereoselective Synthesis of Tricyclic Diproline Analogues that Mimic a PPII Helix: Structural Consequences of Ring-Size Variation, A. Soicke, C. Reuter, M. Winter, J. M. Neudorfl, N. Schlorer, R. Kuhne, H. G. Schmalz, Eur. J. Org. Chem., 2014, 2014 (29), 6467. 10.1002/ejoc.201402737

[50] Synthesis of Indole-Derived Allocolchicine Congeners through Pd-Catalyzed Intramolecular C-H Arylation Reaction, N. S. Sitnikov, A. S. Kokisheva, G. K. Fukin, J. M. Neudorfl, H. Sutorius, A. Prokop, V. V. Fokin, H. G. Schmalz, A. Y. Fedorov, Eur. J. Org. Chem., 2014, 2014 (29), 6481. 10.1002/ejoc.201402850

[51] Enzyme-triggered CO-releasing molecules (ET-CORMs), H. G. Schmalz, J. Biol. Inorg. Chem., 2014, 19, S719.

[52] Stereoselective Synthesis of Proline- Derived Dipeptide Scaffolds ( ProM-3 and ProM-7) Rigidified in a PPII Helix Conformation, C. Reuter, M. Kleczka, S. de Mazancourt, J. M. Neudorfl, R. Kuhne, H. G. Schmalz, Eur. J. Org. Chem., 2014, 2014 (13), 2664. 10.1002/ejoc.201301875

[53] New modular manganese(I) tricarbonyl complexes as PhotoCORMs: in vitro detection of photoinduced carbon monoxide release using COP-1 as a fluorogenic switch-on probe, S. Pai, M. Hafftlang, G. Atongo, C. Nagel, J. Niesel, S. Botov, H. G. Schmalz, B. Yard, U. Schatzschneider, Dalton Trans., 2014, 43 (23), 8664. 10.1039/c4dt00254g

[54] Asymmetric catalytic arylation of ethyl glyoxylate using organoboron reagents and Rh(I)-phosphane and phosphane-phosphite catalysts, C. S. Marques, M. Dindaroglu, H. G. Schmalz, A. J. Burke, RSC Adv., 2014, 4 (12), 6035. 10.1039/c3ra47000h

[55] Aryl-Phenyl Scrambling in Intermediate Organopalladium Complexes: A Gas-Phase Study of the Mizoroki-Heck Reaction, L. Fiebig, N. Schlorer, H. G. Schmalz, M. Schafer, Chem. Eur. J., 2014, 20 (17), 4906. 10.1002/chem.201400115

[56] Synthesis of C-2-Symmetric Bisphosphine Ligands from Tartaric Acid, and Their Performance in the Pd-Catalyzed Asymmetric O-Allylation of a Phenol, M. Dindaroglu, A. Dincer, H. G. Schmalz, Eur. J. Org. Chem., 2014, 2014 (20), 4315. 10.1002/ejoc.201402326

[57] Structure-Activity Relationships of Novel 2-Benzyl-3-Phenylisoindolinones as Inhibitors of Cholesterol Esterase, M. Steinkruger, D. Augner, T. Mielke, M. Gutschow, S. Herzig, H. G. Schmalz, M. Pietsch, Naunyn-Schmiedeberg's Arch. Pharmacol., 2013, 386, S80.

[58] ENZYME-TRIGGERED CO-RELEASING MOLECULES (ET-CORMS): EVALUATION OF BIOLOGICAL ACTIVITY IN RELATION TO THEIR STRUCTURE, E. Stamellou, S. Romanski, S. Amslinger, M. Hafner, B. Kramer, H. G. Schmalz, B. A. Yard, Transpl. Int., 2013, 26, 56.

[59] Identification and Kinetic Characterization of Novel Inhibitors of Human Cholesterol Esterase as Anti-Atherosclerotic Agents, M. Sheikh, M. Steinkruger, D. Augner, M. Gutschow, S. Herzig, H. G. Schmalz, M. Pietsch, Naunyn-Schmiedeberg's Arch. Pharmacol., 2013, 386, S78.

[60] Enzyme-triggered CO-releasing molecules (ET-CORMs): Evaluation of biological activity in relation to their structure, S. Romanski, E. Stamellou, J. T. Jaraba, D. Storz, B. K. Kramer, M. Hafner, S. Amslinger, H. G. Schmalz, B. A. Yard, Free Radical Biol. Med., 2013, 65, 78. 10.1016/j.freeradbiomed.2013.06.014

[61] Lipophilic prodrugs of a triazole-containing colchicine analogue in liposomes: Biological effects on human tumor cells, N. R. Kuznetsova, E. V. Svirshchevskaya, N. S. Sitnikov, L. Abodo, H. Sutorius, J. Zapke, J. Velder, P. Thomopoulou, H. Oschkinat, A. Prokop, H. G. Schmalz, A. Y. Fedorov, E. L. Vodovozova, Rus. J. Bioorg. Chem., 2013, 39 (5), 543. 10.1134/s1068162013050105

[62] Nucleoside Analogues with a 1,3-Diene-Fe(CO)(3) Substructure: Stereoselective Synthesis, Configurational Assignment, and Apoptosis-Inducing Activity, C. Hirschhauser, J. Velcicky, D. Schlawe, E. Hessler, A. Majdalani, J. M. Neudorfl, A. Prokop, T. Wieder, H. G. Schmalz, Chem. Eur. J., 2013, 19 (39), 13017. 10.1002/chem.201301672

[63] Efficient -Helix Induction in a Linear Peptide Chain by N-Capping with a ridged-tricyclic Diproline Analogue, V. Hack, C. Reuter, R. Opitz, P. Schmieder, M. Beyermann, J. M. Neudorfl, R. Kuhne, H. G. Schmalz, Angew. Chem. Int. Ed., 2013, 52 (36), 9539. 10.1002/anie.201302014

[64] Cobalt Catalysis in the Gas Phase: Experimental Characterization of Cobalt(I) Complexes as Intermediates in Regioselective Diels-Alder Reactions, L. Fiebig, J. Kuttner, G. Hilt, M. C. Schwarzer, G. Frenking, H. G. Schmalz, M. Schafer, J. Org. Chem., 2013, 78 (20), 10485. 10.1021/jo402001g

[65] Enantioselective Nickel-Catalyzed Hydrocyanation of Vinylarenes Using Chiral Phosphine-Phosphite Ligands and TMS-CN as a Source of HCN, A. Falk, A. L. Goderz, H. G. Schmalz, Angew. Chem. Int. Ed., 2013, 52 (5), 1576. 10.1002/anie.201208082

[66] A Scalable Synthesis of Chiral Modular Phosphine-Phosphite Ligands, M. Dindaroglu, A. Falk, H. G. Schmalz, Synthesis, 2013, 45 (4), 527. 10.1055/s-0032-1316847

[67] TARTROL-derived chiral phosphine-phosphite ligands and their performance in enantioselective Cu-catalyzed 1,4-addition reactions, M. Dindaroglu, S. Akyol, H. Simsir, J. M. Neudorfl, A. Burke, H. G. Schmalz, Tetrahedron: Asymmetry, 2013, 24 (11), 657. 10.1016/j.tetasy.2013.04.008

[68] Synthesis and Performance of Acyloxy-diene-Fe(CO)(3) Complexes with Variable Chain Lengths as Enzyme-Triggered Carbon Monoxide-Releasing Molecules, S. Botov, E. Stamellou, S. Romanski, M. Guttentag, R. Alberto, J. M. Neudorfl, B. Yard, H. G. Schmalz, Organometallics, 2013, 32 (13), 3587. 10.1021/om301233h

[69] On the Antibiotic and Antifungal Activity of Pestalone, Pestalachloride A, and Structurally Related Compounds, D. Augner, O. Krut, N. Slavov, D. C. Gerbino, H. G. Sahl, J. Benting, C. F. Nising, S. Hillebrand, M. Kronke, H. G. Schmalz, J. Nat. Prod., 2013, 76 (8), 1519. 10.1021/np400301d

[70] Synthesis of Oxa-B-Ring Analogs of Colchicine through Rh-Catalyzed Intramolecular 5+2 Cycloaddition, A. O. Termath, S. Ritter, M. Konig, D. P. Kranz, J. M. Neudorfl, A. Prokop, H. G. Schmalz, Eur. J. Org. Chem., 2012, 2012 (24), 4501. 10.1002/ejoc.201200677

[71] Enzyme-Triggered CO-Releasing Molecules (ET-CORMs): Structural Entities that Mediate Restricted Cell Specificity for CO Release, E. Stamellou, S. Romanski, S. Amslinger, M. Hafner, B. K. Kraemer, H. G. Schmalz, B. A. Yard, Transplantation, 2012, 94 (10), 1134. 10.1097/00007890-201211271-02252

[72] Total Synthesis of Indole-Derived Allocolchicine Analogues Exhibiting Strong Apoptosis-Inducing Activity, N. Sitnikov, J. Velder, L. Abodo, N. Cuvelier, J. Neudorfl, A. Prokop, G. Krause, A. Y. Fedorov, H. G. Schmalz, Chem. Eur. J., 2012, 18 (38), 12096. 10.1002/chem.201200083

[73] Hydrophenalene-Cr(CO)(3) complexes as anti-inflammatory agents based on specific inhibition of NOD2 signalling: a SAR study, A. Saiai, H. Bielig, J. Velder, J. M. Neudorfl, M. Menning, T. A. Kufer, H. G. Schmalz, MedChemComm, 2012, 3 (11), 1377. 10.1039/c2md20221b

[74] Iron Dienylphosphate Tricarbonyl Complexes as Water-Soluble Enzyme-Triggered CO-Releasing Molecules (ET-CORMs), S. Romanski, H. Rucker, E. Stamellou, M. Guttentag, J. M. Neudorfl, R. Alberto, S. Amslinger, B. Yard, H. G. Schmalz, Organometallics, 2012, 31 (16), 5800. 10.1021/om300359a

[75] Acyloxybutadiene tricarbonyl iron complexes as enzyme-triggered CO-releasing molecules (ET-CORMs): a structure-activity relationship study, S. Romanski, B. Kraus, M. Guttentag, W. Schlundt, H. Rucker, A. Adler, J. M. Neudorfl, R. Alberto, S. Amslinger, H. G. Schmalz, Dalton Trans., 2012, 41 (45), 13862. 10.1039/c2dt30662j

[76] Cu-Catalyzed Enantioselective 1,4-Additions of Aryl-Grignard Reagents to Cyclohexenone in the Presence of TADDOL-Derived Phosphane-Phosphite Ligands, Q. Naeemi, M. Dindaroglu, D. P. Kranz, J. Velder, H. G. Schmalz, Eur. J. Org. Chem., 2012, 2012 (6), 1179. 10.1002/ejoc.201101258

[77] An Enantioselective Total Synthesis of Helioporins C and E, W. Lolsberg, S. Werle, J. M. Neudorfl, H. G. Schmalz, Org. Lett., 2012, 14 (23), 5996. 10.1021/ol302898h

[78] Molecular Oxygen as a Redox Catalyst in Intramolecular Photocycloadditions of Coumarins, D. P. Kranz, A. G. Griesbeck, R. Alle, R. Perez-Ruiz, J. M. Neudorfl, K. Meerholz, H. G. Schmalz, Angew. Chem. Int. Ed., 2012, 51 (24), 6000. 10.1002/anie.201201222

[79] Synthesis of B-Ring-Modified Steroids through BF3-Promoted Rearrangement/Substitution of 6 beta-Hydroxy-5,19-cyclosteroids, D. P. Kranz, S. Chiha, A. M. Z. Greffen, J. M. Neudorfl, H. G. Schmalz, Org. Lett., 2012, 14 (14), 3692. 10.1021/ol301532w

[80] A novel conjugate of a cell-penetrating peptide and a ferrocenyl amino acid: a potential electrochemical sensor for living cells?, J. Hoyer, A. Hunold, H. G. Schmalz, I. Neundorf, Dalton Trans., 2012, 41 (21), 6396. 10.1039/c2dt12211a

[81] Nucleophile- or Light-Induced Synthesis of 3-Substituted Phthalides from 2-Formylarylketones, D. C. Gerbino, D. Augner, N. Slavov, H. G. Schmalz, Org. Lett., 2012, 14 (9), 2338. 10.1021/ol300757m

[82] TADDOL-Based Phosphane-Phosphite Ligands in Enantioselective Cu-Catalyzed Grignard 1,4-Additions Followed by Mannich-Type Alkylations, M. Drusan, W. Lolsberg, A. Skvorcova, H. G. Schmalz, R. Sebesta, Eur. J. Org. Chem., 2012, 2012 (31), 6285. 10.1002/ejoc.201200729

[83] Ligand Control of the Cobalt-Catalysed 1,4-Hydrovinylation Reaction, M. Arndt, M. Dindaroglu, H. G. Schmalz, G. Hilt, Synthesis, 2012, 44 (22), 3534. 10.1055/s-0032-1316796

[84] Palladium-Catalyzed Cyanomethylation of Aryl Halides through Domino Suzuki Coupling-Isoxazole Fragmentation, J. Velcicky, A. Soicke, R. Steiner, H. G. Schmalz, J. Am. Chem. Soc., 2011, 133 (18), 6948. 10.1021/ja201743j

[85] Metal-Free Intramolecular Carbonyl-Olefin Metathesis of ortho-Prenylaryl Ketones, A. Soicke, N. Slavov, J. M. Neudorfl, H. G. Schmalz, Synlett, 2011,  (17), 2487. 10.1055/s-0030-1260320

[86] Enantioselective Access to 3-Methylene-1H-indanol through Asymmetric Domino Allylstannylation-Heck Reaction, J. Schutte, S. T. Ye, H. G. Schmalz, Synlett, 2011,  (18), 2725. 10.1055/s-0031-1289539

[87] (RS)-Tricarbonyl(eta(4)-1,3-diacetoxy-5,5-dimethylcyclohexa-1,3-diene) iron(0), S. Romanski, J. M. Neudorfl, H. G. Schmalz, Acta Crystallogr., Sect. E: Struct. Rep. Online, 2011, 67, M1530. 10.1107/s1600536811041298

[88] Acyloxybutadiene-Iron Tricarbonyl Complexes as Enzyme-Triggered CO-Releasing Molecules (ET-CORMs) (vol 50, pg 2392, 2011), S. Romanski, B. Kraus, U. Schatzschneider, J. M. Neudorfl, S. Amslinger, H. G. Schmalz, Angew. Chem. Int. Ed., 2011, 50 (18).

[89] Acyloxybutadiene Iron Tricarbonyl Complexes as Enzyme-Triggered CO-Releasing Molecules (ET-CORMs), S. Romanski, B. Kraus, U. Schatzschneider, J. M. Neudorfl, S. Amslinger, H. G. Schmalz, Angew. Chem. Int. Ed., 2011, 50 (10), 2392. 10.1002/anie.201006598

[90] Exercises in Pyrrolidine Chemistry: Gram Scale Synthesis of a Pro-Pro Dipeptide Mimetic with a Polyproline Type II Helix Conformation, C. Reuter, P. Huy, J. M. Neudorfl, R. Kuhne, H. G. Schmalz, Chem. Eur. J., 2011, 17 (43), 12037. 10.1002/chem.201101704

[91] A CONVENIENT ENTRY TO NEW C-7-MODIFIED COLCHICINOIDS THROUGH AZIDE ALKYNE 3+2 CYCLOADDITION: APPLICATION OF RING-CONTRACTIVE REARRANGEMENTS, N. Nicolaus, J. Reball, N. Sitnikov, J. Velder, A. Termath, A. Y. Fedorov, H. G. Schmalz, Heterocycles, 2011, 82 (2), 1585. 10.3987/com-10-s(e)117

[92] Total Synthesis of cyclo-Mumbaistatin Analogues through Anionic Homo-Fries Rearrangement, S. Neufeind, N. Hulsken, J. M. Neudorfl, N. Schlorer, H. G. Schmalz, Chem. Eur. J., 2011, 17 (9), 2633. 10.1002/chem.201003166

[93] Chiral phosphine-phosphite ligands in the enantioselective 1,4-addition of Grignard reagents to alpha,beta-unsaturated carbonyl compounds, Q. Naeemi, T. Robert, D. P. Kranz, J. Velder, H. G. Schmalz, Tetrahedron: Asymmetry, 2011, 22 (8), 887. 10.1016/j.tetasy.2011.04.018

[94] Sn(OTf)(2) as an Effective Lewis Acid in Reactions of Cyclopropyl Ketones with Acetic Anhydride: Application in the Synthesis of a 19-Nor-B-homo Steroid, D. P. Kranz, A. M. Z. Greffen, S. El Sheikh, J. M. Neudorfl, H. G. Schmalz, Eur. J. Org. Chem., 2011, 2011 (15), 2860. 10.1002/ejoc.201100020

[95] Stereoselective Synthesis and Biological Evaluation of Ferrocene-Containing 5-Hydroxyeicosatetraenoic Acid Analogues, N. Kausch-Busies, J. M. Neudorfl, P. Wefelmeier, A. Prokop, H. Kuhn, H. G. Schmalz, Eur. J. Org. Chem., 2011, 2011 (24), 4634. 10.1002/ejoc.201100003

[96] Synthesis and First Biological Evaluation of an Iron-Containing HETE Analogue, N. Kausch-Busies, B. Kater, J. M. Neudorfl, A. Prokop, H. G. Schmalz, Eur. J. Org. Chem., 2011, 2011 (6), 1133. 10.1002/ejoc.201001445

[97] Iron containing anti-tumoral agents: unexpected apoptosis-inducing activity of a ferrocene amino acid derivative, B. Kater, A. Hunold, H. G. Schmalz, L. Kater, B. Bonitzki, P. Jesse, A. Prokop, J. Cancer Res. Clin. Oncol., 2011, 137 (4), 639. 10.1007/s00432-010-0924-6

[98] Practical One-Pot Double Functionalizations of Proline, P. Huy, H. G. Schmalz, Synthesis, 2011,  (6), 954. 10.1055/s-0030-1258428

[99] A Practical Synthesis of Trans-3-Substituted Proline Derivatives through 1,4-Addition, P. Huy, J. M. Neudorfl, H. G. Schmalz, Org. Lett., 2011, 13 (2), 216. 10.1021/ol102613z

[100] Heck coupling in the gas phase: Examination of the reaction mechanism by ion/molecule reactions and mass spectrometry, L. Fiebig, H. G. Schmalz, M. Schafer, Int. J. Mass Spectrom., 2011, 308 (2-3), 307. 10.1016/j.ijms.2011.07.013

[101] Rhodium-Catalyzed Enantioselective Intramolecular 4+2 Cycloaddition using a Chiral Phosphine-Phosphite Ligand: Importance of Microwave-Assisted Catalyst Conditioning, A. Falk, L. Fiebig, J. M. Neudorfl, A. Adler, H. G. Schmalz, Adv. Synth. Cat., 2011, 353 (18), 3357. 10.1002/adsc.201100658

[102] Paraoxonase-1 is a major determinant of clopidogrel efficacy, H. J. Bouman, E. Schomig, J. W. van Werkum, J. Velder, C. M. Hackeng, C. Hirschhauser, C. Waldmann, H. G. Schmalz, J. M. ten Berg, D. Taubert, Nat. Med., 2011, 17 (1), 110. 10.1038/nm.2281

[103] Paraoxonase-1 is a major determinant of clopidogrel efficacy (vol 17, pg 110, 2011), H. J. Bouman, E. Schomig, J. W. van Werkum, J. Velder, C. M. Hackeng, C. Hirschhauser, C. Waldmann, H. G. Schmalz, J. M. ten Berg, D. Taubert, Nat. Med., 2011, 17 (9), 1153.

[104] Paraoxonase-1 and clopidogrel efficacy reply, H. J. Bouman, E. Schomig, J. W. van Werkum, J. Velder, C. M. Hackeng, C. Hirschhauser, C. Waldmann, H. G. Schmalz, J. M. ten Berg, D. Taubert, Nat. Med., 2011, 17 (9), 1042. 10.1038/nm.2469

[105] Cobalt-Catalyzed 1,4-Hydrobutadienylation of 1-Aryl-1,3-dienes with 2,3-Dimethyl-1,3-butadiene, M. A. Bohn, A. Schmidt, G. Hilt, M. Dindaroglu, H. G. Schmalz, Angew. Chem. Int. Ed., 2011, 50 (41), 9689. 10.1002/anie.201103613

[106] N-Capping of Primary Amines with 2-Acyl-benzaldehydes To Give Isoindolinones, D. Augner, D. C. Gerbino, N. Slavov, J. M. Neudorfl, H. G. Schmalz, Org. Lett., 2011, 13 (19), 5374. 10.1021/ol202271k

[107] Gaining Absolute Control of the Regiochemistry in the Cobalt-Catalyzed 1,4-Hydrovinylation Reaction, M. Arndt, M. Dindaroglu, H. G. Schmalz, G. Hilt, Org. Lett., 2011, 13 (23), 6236. 10.1021/ol202696n

[108] Addressing Protein-Protein Interactions with Small Molecules: A Pro-Pro Dipeptide Mimic with a PPII Helix Conformation as a Module for the Synthesis of PRD-Binding Ligands, J. Zaminer, C. Brockmann, P. Huy, R. Opitz, C. Reuter, M. Beyermann, C. Freund, M. Muller, H. Oschkinat, R. Kuhne, H. G. Schmalz, Angew. Chem. Int. Ed., 2010, 49 (39), 7111. 10.1002/anie.201001739

[109] A Scalable Synthesis of (+/-)-2-Oxoclopidogrel, J. Velder, C. Hirschhauser, C. Waldmann, D. Taubert, H. J. Bouman, H. G. Schmalz, Synlett, 2010,  (3), 467. 10.1055/s-0029-1219177

[110] Total Synthesis of the Marine Antibiotic Pestalone and its Surprisingly Facile Conversion into Pestalalactone and Pestalachloride A, N. Slavov, J. Cvengros, J. M. Neudorfl, H. G. Schmalz, Angew. Chem. Int. Ed., 2010, 49 (41), 7588. 10.1002/anie.201003755

[111] Asymmetric Hydroformylation Using Taddol-Based Chiral Phosphine-Phosphite Ligands, T. Robert, Z. Abiri, J. Wassenaar, A. J. Sandee, S. Romanski, J. M. Neudorfl, H. G. Schmalz, J. N. H. Reek, Organometallics, 2010, 29 (2), 478. 10.1021/om9009735

[112] Phenol-derived chiral phosphine-phosphite ligands in the rhodium-catalyzed enantioselective hydrogenation of functionalized olefins, T. Robert, Z. Abiri, A. J. Sandee, H. G. Schmalz, J. N. H. Reek, Tetrahedron: Asymmetry, 2010, 21 (21-22), 2671. 10.1016/j.tetasy.2010.10.026

[113] Potassium (1-methoxycarbonyl-2-methylprop-2-en-2-ylidene)azinate, C. Reuter, J. M. Neudorfl, H. G. Schmalz, Acta Crystallogr., Sect. E: Struct. Rep. Online, 2010, 66, M461. 10.1107/s1600536810010159

[114] Azides Derived from Colchicine and their Use in Library Synthesis: a Practical Entry to New Bioactive Derivatives of an Old Natural Drug, N. Nicolaus, J. Zapke, P. Riesterer, J. M. Neudorfl, A. Prokop, H. Oschkinat, H. G. Schmalz, ChemMedChem, 2010, 5 (5), 661. 10.1002/cmdc.201000063

[115] Synthesis of Novel Allocolchicine Analogues with a Pyridine C-Ring through Intermolecular Vollhardt Diyne-Nitrile Cyclotrimerization, N. Nicolaus, H. G. Schmalz, Synlett, 2010,  (14), 2071. 10.1055/s-0030-1258512

[116] Enantioselective Copper-Catalysed Allylic Alkylation of Cinnamyl Chlorides by Grignard Reagents using Chiral Phosphine-Phosphite Ligands, W. Loelsberg, S. Ye, H. G. Schmalz, Adv. Synth. Cat., 2010, 352 (11-12), 2023. 10.1002/adsc.201000213

[117] Stereospecificity of the Au(I)-catalyzed reaction of 1-alkynyl-bicyclo 4.1.0 -heptan-2-ones with nucleophiles, S. Labsch, S. Ye, A. Adler, J. M. Neudorfl, H. G. Schmalz, Tetrahedron: Asymmetry, 2010, 21 (13-14), 1745. 10.1016/j.tetasy.2010.05.019

[118] New caspase-independent but ROS-dependent apoptosis pathways are targeted in melanoma cells by an iron-containing cytosine analogue, J. C. Franke, M. Plotz, A. Prokop, C. C. Geilen, H. G. Schmalz, J. Eberle, Biochem. Pharmacol., 2010, 79 (4), 575. 10.1016/j.bcp.2009.09.022

[119] New caspase-independent but ROS-dependent apoptosis pathways are targeted in melanoma cells by an iron-containing cytosine analogue, J. C. Franke, M. Plotz, C. C. Geilen, H. Schmalz, A. Prokop, J. Eberle, Exp. Dermatol., 2010, 19 (2), 211.

[120] Induction of apoptosis in Melanoma cells a new caspase-independent but ROS-dependent signaling pathways, J. Eberle, J. C. Franke, M. Plotz, A. Prokop, C. C. Geilen, H. G. Schmalz, Onkologie, 2010, 33, 145.

[121] Anti-inflammatory Arene-Chromium Complexes Acting as Specific Inhibitors of NOD2 Signalling, H. Bielig, J. Velder, A. Saiai, M. Menning, S. Meemboor, W. Kalka-Moll, M. Kronke, H. G. Schmalz, T. A. Kufer, ChemMedChem, 2010, 5 (12), 2065. 10.1002/cmdc.201000320

[122] trans-1,2-Bis(3,5-dimethoxyphenyl)ethene, S. Ritter, J. M. Neudorfl, J. Velder, H. G. Schmalz, Acta Crystallogr., Sect. E: Struct. Rep. Online, 2009, 65, O2150. 10.1107/s160053680903116x

[123] trans-Ethylenedi-p-phenylene diacetate, S. Ritter, J. M. Neudorfl, J. Velder, H. G. Schmalz, Acta Crystallogr., Sect. E: Struct. Rep. Online, 2009, 65, O2229. 10.1107/s1600536809032620

[124] A 2+2+2 -Cycloaddition Approach toward 6-Oxa-allocolchicinoids with Apoptosis-inducing Activity, N. Nicolaus, S. Strauss, J. M. Neudorfl, A. Prokop, H. G. Schmalz, Org. Lett., 2009, 11 (2), 341. 10.1021/ol802542c

[125] Stereoselective Synthesis of New Ferrocene-Derived Amino Acid Building Blocks, A. Hunold, I. Neundorf, P. James, J. Neudorfl, H. G. Schmalz, Eur. J. Org. Chem., 2009, 2009 (26), 4429. 10.1002/ejoc.200900552

[126] Introduction of Allyl and Prenyl Side-Chains into Aromatic Systems by Suzuki Cross-Coupling Reactions, D. C. Gerbino, S. D. Mandolesi, H. G. Schmalz, J. C. Podesta, Eur. J. Org. Chem., 2009, 2009 (23), 3964. 10.1002/ejoc.200900234

[127] Electrophilic Activation of Benzaldehydes through ortho Palladation: One-Pot Synthesis of 3-Methylene-indan-1-ols through a Domino Allylstannylation/Heck Reaction under Neutral Conditions, J. Cvengros, J. Schutte, N. Schlorer, J. Neudorfl, H. G. Schmalz, Angew. Chem. Int. Ed., 2009, 48 (33), 6148. 10.1002/anie.200901837

[128] Modular synthesis of chiral phosphine-phosphite-ligands from phenolic precursors: A new approach to bidentate chelate ligands exploiting a P-O to P-C migration rearrangement, J. Velder, T. Robert, I. Weidner, J. M. Neudorfl, J. Lex, H. G. Schmalz, Adv. Synth. Cat., 2008, 350 (9), 1309. 10.1002/adsc.200800146

[129] Enantioselective Cu-catalyzed 1,4-addition of Grignard reagents to cyclohexenone using Taddol-derived phosphine-phosphite ligands and 2-methyl-THF as a solvent, T. Robert, J. Velder, H. G. Schmalz, Angew. Chem. Int. Ed., 2008, 47 (40), 7718. 10.1002/anie.200803247

[130] Butyllithium-mediated coupling of aryl bromides with ketones under in-situ-quench (ISQ) conditions: An efficient one-step protocol applicable to microreactor technology, S. Goto, J. Velder, S. El Sheikh, Y. Sakamoto, M. Mitani, S. Elmas, A. Adler, A. Becker, J. M. Neudorfl, J. Lex, H. G. Schmalz, Synlett, 2008,  (9), 1361. 10.1055/s-2008-1072771

[131] The iron-containing nucleoside analogue N69 efficiently induces apoptosis inhuman melanoma cells by activating new pathways enclosing lysosomalactivation, J. C. Franke, A. Prokop, D. Schlawe, H. Schmalz, J. Eberle, Exp. Dermatol., 2008, 17 (3), 278.

[132] Microwave-assisted cleavage of aryl methyl ethers with lithium thioethoxide (LiSEt), J. Cvengros, S. Neufeind, A. Becker, H. G. Schmalz, Synlett, 2008,  (13), 1993. 10.1055/s-2008-1077949

[133] Enantioselective Synthesis of a trans-7,8-Dimethoxycalamenene, S. Werle, T. Fey, J. M. Neudorfl, H. G. Schmalz, Org. Lett., 2007, 9 (18), 3555. 10.1021/ol071228v

[134] Enantioselective synthesis of a trans-7,8-dimethoxycalamenene (vol 9, pg 3556, 2007), S. Werle, T. Fey, J. M. Neudorfl, H. G. Schmalz, Org. Lett., 2007, 9 (20), 4085. 10.1021/ol702069a

[135] Synthesis of a mumbaistatin analogue through cross-coupling, D. Sucunza, D. Dembkowski, S. Neufeind, J. Velder, J. Lex, H. G. Schmalz, Synlett, 2007,  (16), 2569. 10.1055/s-2007-986652

[136] Synthesis of 4-benzyliden-2-oxazolidinone derivatives via gold-catalyzed intramolecular hydroamination, S. Ritter, K. Hackeloer, H. G. Schmalz, Heterocycles, 2007, 74, 731.

[137] Stereospecific side chain activation in Cyclobutadiene-Fe(CO)(3) chemistry: A theoretical and experimental study on the structure and configurational stability of cationic, radical and anionic intermediates, A. Pfletschinger, U. Schneider, J. Lex, H. G. Schmalz, Eur. J. Org. Chem., 2007, 2007 (24), 3991. 10.1002/ejoc.200700342

[138] Stereoselective syntheses of the 2-isopropenyl-2,3-dihydrobenzofuran nucleus: Potential chiral building blocks for the syntheses of tremetone, hydroxytremetone, and rotenone, S. C. Pelly, S. Govender, M. A. Fernandes, H. G. Schmalz, C. B. de Koning, J. Org. Chem., 2007, 72 (8), 2857. 10.1021/jo062447h

[139] Synthesis of the core structure of the cyclocitrinols via SmI(2)-mediated fragmentation of a cyclopropane precursor, S. El Sheikh, A. M. Z. Greffen, J. Lex, J. M. Neudorfl, H. G. Schmalz, Synlett, 2007,  (12), 1881. 10.1055/s-2007-984521

[140] Gold(I)-catalyzed reaction of 1-(1-alkynyl)-cyclopropyl ketones with nucleophiles: A modular entry to highly substituted furans, J. L. Zhang, H. G. Schmalz, Angew. Chem. Int. Ed., 2006, 45 (40), 6704. 10.1002/anie.200601252

[141] A simple access to biologically important trans-stilbenes via Ru-catalyzed cross metathesis, J. Velder, S. Ritter, J. Lex, H. G. Schmalz, Synthesis, 2006,  (2), 273. 10.1055/s-2005-918506

[142] Gram-scale synthesis of pinusolide and evaluation of its antileukemic potential, E. E. Shults, J. Velder, H. G. Schmalz, S. V. Chernov, T. V. Rubalova, Y. V. Gatilov, G. Henze, G. A. Tolstikov, A. Prokop, Bioorg. Med. Chem. Lett., 2006, 16 (16), 4228. 10.1016/j.bmcl.2006.05.077

[143] Gold-catalyzed cyclization of O-propargyl carbamates under mild conditions: A convenient access to 4-alkylidene-2-oxazolidinones, S. Ritter, Y. Horino, J. Lex, H. G. Schmalz, Synlett, 2006,  (19), 3309. 10.1055/s-2006-951555

[144] Ferrocenyl nucleoside analogs, a new class of cytostatic drugs, overcome multiple drug resistance in acute lymphoplastic leukemia ex vivo, A. Prokop, M. Eissmann, P. Jesse, G. Henze, P. James, J. Neudoerfl, H. G. Schmalz, H. Lode, Blood, 2006, 108 (11), 179B. 10.1182/blood.V108.11.4404.4404

[145] New pinostilbene analogues overcome anthracycline resistance in acute lymphoplastic leukemia ex vivo, B. Katik, A. Selig, J. Velder, E. E. Shults, T. Wieder, G. Henze, H. G. Schmalz, A. Prokop, H. Lode, Blood, 2006, 108 (11), 178B. 10.1182/blood.V108.11.4403.4403

[146] Enantioselective synthesis of ferrocenyl nucleoside analogues with apoptosis-inducing activity, P. James, J. Neudorfl, M. Eissmann, P. Jesse, A. Prokop, H. G. Schmalz, Org. Lett., 2006, 8 (13), 2763. 10.1021/ol060868f

[147] Enantioselective synthesis of bicyclo 4.4.1 undecane-2,7-dione via samarium(II)-mediated fragmentation of a cyclopropane precursor, S. El Sheikh, N. Kausch, J. Lex, J. M. Neudorfl, H. G. Schmalz, Synlett, 2006,  (10), 1527. 10.1055/s-2006-941599

[148] Microwave-assisted amination of a chloropurine derivative in the synthesis of acyclic nucleoside analogues, A. Lanver, H. G. Schmalz, Molecules, 2005, 10 (2), 508. 10.3390/10020508

[149] A Pauson-Khand approach to new carbocyclic nucleoside analogs, A. Lanver, H. G. Schmalz, Eur. J. Org. Chem., 2005, 2005 (7), 1444. 10.1002/ejoc.200400886

[150] Enantioselective organocatalysis in ionic liquids: Addition of aliphatic aldehydes and ketones to diethyl azodicarboxylate, P. Kotrusz, S. Alemayehu, T. Toma, H. G. Schmalz, A. Adler, Eur. J. Org. Chem., 2005, 2005 (22), 4904. 10.1002/ejoc.200500481

[151] Total synthesis of (-)-colchicine via a Rh-triggered cycloaddition cascade, T. Graening, V. Bette, J. Neudorfl, J. Lex, H. G. Schmalz, Org. Lett., 2005, 7 (20), 4317. 10.1021/ol051316k

[152] Transition-metal-mediated synthesis of novel carbocyclic nucleoside analogues with antitumoral activity, J. Velcicky, A. Lanver, J. Lex, A. Prokop, T. Wieder, H. G. Schmalz, Chem. Eur. J., 2004, 10 (20), 5087. 10.1002/chem.200400079

[153] Iron-containing nucleoside analogues with pronounced apoptosis-inducing activity, D. Schlawe, A. Majdalani, J. Velcicky, E. Hessler, T. Wieder, A. Prokop, H. G. Schmalz, Angew. Chem. Int. Ed., 2004, 43 (13), 1731. 10.1002/anie.200353132

[154] Iron containing nucleosides as new cytostatic substances for cancer and leukemia therapy, especially for therapy of relapsed ALL in childhood, A. Prokop, T. Wieder, D. Schlawe, H. Lode, G. Henze, P. T. Daniel, H. G. Schmalz, Blood, 2004, 104 (11), 574A. 10.1182/blood.V104.11.2085.2085

[155] Application of chromium-arene complexes in the organic synthesis. Efficient synthesis of stilbene phytoalexins, K. E. Polunin, H. G. Schmalz, Rus. J. Coord. Chem., 2004, 30 (4), 252. 10.1023/B:RUCO.0000022800.70211.7d

[156] Michael additions of aldehydes and ketones to beta-nitrostyrenes in an ionic liquid, P. Kotrusz, S. Toma, H. G. Schmalz, A. Adler, Eur. J. Org. Chem., 2004, 2004 (7), 1577. 10.1002/ejoc.200300648

[157] Total syntheses of colchicine in comparison: A journey through 50 years of synthetic organic chemistry, T. Graening, H. G. Schmalz, Angew. Chem. Int. Ed., 2004, 43 (25), 3230. 10.1002/anie.200300615

[158] Halogen-lithium exchange reactions under in situ-quench conditions: A powerful concept for organic synthesis, S. El Sheikh, H. G. Schmalz, Curr. Opin. Drug Discovery Dev., 2004, 7 (6), 882.

[159] Pd-catalyzed cross-coupling of haloarenes and chloroarene-Cr(CO)(3) complexes with stabilized vinyl- and allylaluminium reagents, H. Schumann, J. Kaufmann, H. G. Schmalz, A. Bottcher, B. Gotov, Synlett, 2003,  (12), 1783. 10.1055/s-2003-41492

[160] An enantioselective approach to cytotoxic norcalamenenes via electron-transfer-driven benzylic umpolung of an arene tricarbonyl chromium complex, H. G. Schmalz, O. Kiehl, U. Korell, J. Lex, Synthesis, 2003,  (12), 1851. 10.1055/s-2003-41030

[161] Studies towards the total synthesis of mumbaistatin: synthesis of highly substituted benzophenone and anthraquinone building blocks, F. Kaiser, L. Schwink, J. Velder, H. G. Schmalz, Tetrahedron, 2003, 59 (18), 3201. 10.1016/s0040-4020(03)00427-7

[162] Synthetic analogues of the antibiotic pestalone, F. Kaiser, H. G. Schmalz, Tetrahedron, 2003, 59 (37), 7345. 10.1016/s0040-4020(03)01136-0

[163] Pd-catalyzed enantioselective allylic substitution: New strategic options for the total synthesis of natural products, T. Graening, H. G. Schmalz, Angew. Chem. Int. Ed., 2003, 42 (23), 2580. 10.1002/anie.200301644

[164] Catalytic-enantioselective methoxycarbonylation of 1,3-dichloroarene-tricarbonyl-chromium(0) complexes: A desymmetrization approach to planar chirality, A. Bottcher, H. G. Schmalz, Synlett, 2003,  (11), 1595. 10.1055/s-2003-41417

[165] Benzylic endo-alkylation of phthalan-Cr(CO)(3) complexes via temporary silylation: An entry to trans-1,3-disubstituted dihydroisobenzofurans, S. Zemolka, J. Lex, H. G. Schmalz, Angew. Chem. Int. Ed., 2002, 41 (14), 2525. 10.1002/1521-3773(20020715)41:14<2525::Aid-anie2525>3.0.Co;2-o

[166] An efficient organometallic approach to new carbocyclic nucleoside analogues, J. Velcicky, J. Lex, H. G. Schmalz, Org. Lett., 2002, 4 (4), 565. 10.1021/ol017181+

[167] Gram-scale synthesis of suspension-polymerized styrene-divinylbenzene-based resins using an oscillatory baffled reactor, D. C. Sherrington, A. Lanver, H. G. Schmalz, B. Wilson, X. W. Ni, S. G. Yuan, Angew. Chem. Int. Ed., 2002, 41 (19), 3656. 10.1002/1521-3773(20021004)41:19<3656::Aid-anie3656>3.0.Co;2-7

[168] Synthesis and biological evaluation of new antimalarial isonitriles related to marine diterpenoids, O. Schwarz, R. Brun, J. W. Bats, H. G. Schmalz, Tetrahedron Lett., 2002, 43 (6), 1009. 10.1016/s0040-4039(01)02325-5

[169] Diallylaluminium-N,N-dimethylaminoethanolate, the first stable allyl-alane suitable for additions to aldehydes, ketones and imines, H. Schumann, J. Kaufmann, S. Dechert, H. G. Schmalz, Tetrahedron Lett., 2002, 43 (19), 3507. 10.1016/s0040-4039(02)00571-3

[170] Electron transfer driven transformations of transition metal pi-complexes: Samarium(II) iodide mediated coupling of fluoroarene-Cr(CO)(3) complexes with ketones, H. G. Schmalz, O. Kiehl, B. Gotov, Synlett, 2002,  (8), 1253. 10.1055/s-2002-32969

[171] Chromium arene complexes in synthesis of trans-resveratrol, K. E. Polunin, H. G. Schmalz, L. A. Polunina, Rus. Chem. Bull., 2002, 51 (7), 1319. 10.1023/a:1020921101384

[172] eta(6)-Arene-tricarbonylchromium complexes in the syntheses of trans-resveratrol and pinostilbene, K. E. Polunin, I. A. Polunina, H. G. Schmalz, Mendeleev Commun., 2002,  (5), 178. 10.1070/MC2002v012n05ABEH001616

[173] Studies toward the total synthesis of mumbaistatin, a highly potent glucose-6-phosphate translocase inhibitor. Synthesis of a mumbaistatin analogue, F. Kaiser, L. Schwink, J. Velder, H. G. Schmalz, J. Org. Chem., 2002, 67 (26), 9248. 10.1021/jo026232t

[174] Facile construction of the colchicine skeleton by a rhodium-catalyzed cyclization cycloaddition cascade, T. Graening, W. Friedrichsen, J. Lex, H. G. Schmalz, Angew. Chem. Int. Ed., 2002, 41 (9), 1524. 10.1002/1521-3773(20020503)41:9<1524::Aid-anie1524>3.0.Co;2-9

[175] Pd-catalyzed cross-coupling of chloroarene-Cr(CO)(3) complexes with stabilized organoindium (III) reagents under remarkably mild conditions, B. Gotov, J. Kaufmann, H. Schumann, H. G. Schmalz, Synlett, 2002,  (2), 361.

[176] Pd-catalyzed carbonylative cross-coupling reactions of chloroarene-Cr(CO)(3) complexes, B. Gotov, J. Kaufmann, H. Schumann, H. G. Schmalz, Synlett, 2002,  (7), 1161.

[177] An approach to serrulatane diterpenes via endo-selective conjugate nucleophilic addition to arene-Cr(CO)(3) complexes, F. Dehmel, J. Lex, H. G. Schmalz, Org. Lett., 2002, 4 (22), 3915. 10.1021/ol026827a

[178] Identification of suitable ligands for a transition metal-catalyzed reaction: Screening of a modular ligand library in the enantioselective hydroboration of styrene, F. Blume, S. Zemolka, T. Fey, R. Kranich, H. G. Schmalz, Adv. Synth. Cat., 2002, 344 (8), 868. 10.1002/1615-4169(200209)344:8<868::Aid-adsc868>3.0.Co;2-m

[179] Piceatannol, a hydroxylated analog of the chemopreventive agent resveratrol, is a potent inducer of apoptosis in the lymphoma cell line BJAB and in primary, leukemic lymphoblasts, T. Wieder, A. Prokop, B. Bagci, F. Essmann, D. Bernicke, K. Schulze-Osthoff, B. Dorken, H. G. Schmalz, P. T. Daniel, G. Henze, Leukemia, 2001, 15 (11), 1735. 10.1038/sj.leu.2402284

[180] (CH2=CH)(2)Al(mu-OCH2CH2NMe2) (2): a vinylalane reagent suitable for conjugate additions to alpha,beta-unsaturated ketones, H. Schumann, J. Kaufmann, S. Dechert, H. G. Schmalz, J. Velder, Tetrahedron Lett., 2001, 42 (32), 5405. 10.1016/s0040-4039(01)01026-7

[181] Piceatannol, a hydroxylated analog of the chemopreventive agent resveratrol, is a potent inducer of apoptosis in the lymphoma cell line BJAB and in primary, leukemic lymphoblasts, A. Prokop, T. Wieder, B. Bagci, F. Essmann, D. Bernicke, K. Schulze-Osthoff, B. Dorken, H. G. Schmalz, G. Henze, P. T. Daniel, Blood, 2001, 98 (11), 220B.

[182] On the regioselectivity of nucleophilic additions to anisole-Cr(CO)(3) and related complexes: a density functional study, A. Pfletschinger, W. Koch, H. G. Schmalz, New J. Chem., 2001, 25 (3), 446. 10.1039/b002898n

[183] Density functional investigation of reactive intermediates derived from alkyne-CO2(CO)(6) complexes, A. Pfletschinger, W. Koch, H. G. Schmalz, Chem. Eur. J., 2001, 7 (24), 5325. 10.1002/1521-3765(20011217)7:24<5325::Aid-chem5325>3.0.Co;2-s

[184] On the antioxidative activity of several dihydropyridine derivatives, W. Gutwirth, M. Beer, T. Naumann, B. Lauven, K. Guttler, H. G. Schmalz, W. Klaus, Naunyn-Schmiedeberg's Arch. Pharmacol., 2001, 363 (4), R70.

[185] A catalytic-enantioselective entry to planar chiral pi-complexes: Enantioselective methoxycarbonylation of 1,2-dichlorobenzene-Cr(CO)(3), B. Gotov, H. G. Schmalz, Org. Lett., 2001, 3 (11), 1753. 10.1021/ol0159468

[186] Unexpected endo selectivity of conjugate nucleophilic addition to an arene-Cr(CO)(3) complex: Enantioselective synthesis of the diterpene 11-epi-helioporin B, F. Dehmel, H. G. Schmalz, Org. Lett., 2001, 3 (22), 3579. 10.1021/ol016699a

[187] A modular approach to structurally diverse bidentate chelate ligands for transition metal catalysis, R. Kranich, K. Eis, O. Geis, S. Muhle, J. W. Bats, H. G. Schmalz, Chem. Eur. J., 2000, 6 (15), 2874. 10.1002/1521-3765(20000804)6:15<2874::Aid-chem2874>3.3.Co;2-t

[188] Kinetic investigation of the reduction of pinacolone by borane catalyzed by oxazaborolidines in THF. Hydride shift as rate determining step, H. Jockel, R. Schmidt, H. Jope, H. G. Schmalz, J. Chem. Soc. Perkin Trans. 2, 2000,  (1), 69. 10.1039/a906935f

[189] Memory of chirality in electron transfer mediated benzylic umpolung reactions of arene-Cr(CO)(3) complexes, H. G. Schmalz, C. B. de Koning, D. Bernicke, S. Siegel, A. Pfletschinger, Angew. Chem. Int. Ed., 1999, 38 (11), 1620. 10.1002/(sici)1521-3773(19990601)38:11<1620::Aid-anie1620>3.0.Co;2-1

[190] Structural and energetical characterization of the methylbutadiene-Fe(CO)(3) isomers and related reactive intermediates with quantum chemical methods, A. Pfletschinger, H. G. Schmalz, W. Koch, Eur. J. Inorg. Chem., 1999,  (11), 1869.

[191] Structural and energetical characterization of reactive intermediates derived from toluene-Cr(CO)(3), A. Pfletschinger, T. K. Dargel, J. W. Bats, H. G. Schmalz, W. Koch, Chem. Eur. J., 1999, 5 (2), 537. 10.1002/(sici)1521-3765(19990201)5:2<537::Aid-chem537>3.0.Co;2-i

[192] Synthesis of an analog of the cytotoxic marine diterpene helioporin C exploiting arene-Cr(CO)(3) chemistry, D. Horstermann, H. G. Schmalz, G. Kociok-Kohn, Tetrahedron, 1999, 55 (22), 6905. 10.1016/s0040-4020(99)00346-4

[193] 2-aminobenzimidazolium nitrate at 152 K, a triclinic crystal structure with pronounced local pseudo-symmetry, J. W. Bats, D. Gordes, H. G. Schmalz, Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 1999, 55, 1325. 10.1107/s0108270199004710

[194] Highly regioselective benzylic deprotonation of some (η6-tetralin)- and (η6-trans-octahydroanthracene)Cr(CO)(3) derivatives: Is the regioselectivity stereoelectronically controlled?, T. Volk, D. Bernicke, J. W. Bats, H. G. Schmalz, Eur. J. Inorg. Chem., 1998,  (12), 1883.

[195] Electron transfer driven reactions of transition metal pi-complexes: Hydrogenation of styrene-Cr(CO)(3) derivatives by samarium(II)iodide in the presence of water, H. G. Schmalz, S. Siegel, D. Bernicke, Tetrahedron Lett., 1998, 39 (37), 6683. 10.1016/s0040-4039(98)01436-1

[196] On the oxazaborolidine-catalyzed borane reduction of 1-tetralone-Cr(CO)(3) complexes: The control of the reagent over a strong substrate, H. G. Schmalz, H. Jope, Tetrahedron, 1998, 54 (14), 3457. 10.1016/s0040-4020(98)00078-7

[197] Chiral η6-arene-Cr(CO)(3) complexes as synthetic building blocks: A short enantioselective total synthesis of (+)-ptilocaulin, K. Schellhaas, H. G. Schmalz, J. W. Bats, Chem. Eur. J., 1998, 4 (1), 57. 10.1002/(sici)1521-3765(199801)4:1<57::Aid-chem57>3.0.Co;2-h

[198] Electron transfer driven addition of ketimine derived radicals to arene-Cr(CO)(3) complexes, O. Hoffmann, H. G. Schmalz, Synlett, 1998,  (12), 1426.

[199] Chiral arene-Cr(CO)(3) complexes in organic synthesis: A short enantioselective total synthesis of putative helioporin D, T. Geller, H. G. Schmalz, J. W. Bats, Tetrahedron Lett., 1998, 39 (12), 1537. 10.1016/s0040-4039(98)00021-5

[200] Preparation of helioporin D from the seco-pseudopterosin aglycone: Revision of the stereostructure of helioporin D, T. Geller, J. Jakupovic, H. G. Schmalz, Tetrahedron Lett., 1998, 39 (12), 1541. 10.1016/s0040-4039(98)00020-3

[201] New developments in the Pauson-Khand reaction, O. Geis, H. G. Schmalz, Angew. Chem. Int. Ed., 1998, 37 (7), 911. 10.1002/(sici)1521-3773(19980420)37:7<911::Aid-anie911>3.0.Co;2-o

[202] Enantioselective synthesis of new C-2-symmetric ferrocenylalkylamines via sonochemical amination of 1-ferrocenylalkyl acetates, M. Woltersdorf, R. Kranich, H. G. Schmalz, Tetrahedron, 1997, 53 (21), 7219. 10.1016/s0040-4020(97)00407-9

[203] Insertion of carbenoids into Cp-H bonds of ferrocenes: An enantioselective-catalytic entry to planar-chiral ferrocenes, S. Siegel, H. G. Schmalz, Angew. Chem. Int. Ed., 1997, 36 (22), 2456. 10.1002/anie.199724561

[204] Kinetics of the borane reduction of pinacolone in THF catalyzed by two different oxazaboroles, R. Schmidt, H. Jockel, H. G. Schmalz, H. Jope, J. Chem. Soc. Perkin Trans. 2, 1997,  (12), 2725. 10.1039/a703700g

[205] On the deprotonation of η6-1,3-dimethoxybenzene-Cr(CO)(3) derivatives: Influence of the reaction conditions on the regioselectivity, H. G. Schmalz, T. Volk, D. Bernicke, S. Huneck, Tetrahedron, 1997, 53 (27), 9219. 10.1016/s0040-4020(97)00620-0

[206] Chiral η6-arene-Cr(CO)(3) complexes in organic synthesis: A short and highly selective synthesis of the 18-nor-seco-pseudopterosin aglycone, A. Majdalani, H. G. Schmalz, Tetrahedron Lett., 1997, 38 (26), 4545. 10.1016/s0040-4039(97)00995-7

[207] Enantioselective synthesis of the aglycones of pseudopterosin and seco-pseudopterosin via a common synthetic intermediate, A. Majdalani, H. G. Schmalz, Synlett, 1997,  (11), 1303.

[208] Synthesis of (E,E,E)-(1,2,3,4-C-13(4))-geranylgeraniol, K. Eis, H. G. Schmalz, Synthesis, 1997,  (2), 202.

[209] Asymmetric induction in the nucleophile addition to η6-arene-tricarbonyl-chromium(0) complexes, M. F. Semmelhack, H. G. Schmalz, Tetrahedron Lett., 1996, 37 (18), 3089. 10.1016/0040-4039(96)00572-2

[210] Radical cyclization of η6-arene-Cr(CO)(3) complexes: A regio- and stereoselective entry to functionalized pseudopterosin precursors, H. G. Schmalz, S. Siegel, A. Schwarz, Tetrahedron Lett., 1996, 37 (17), 2947. 10.1016/0040-4039(96)00486-8

[211] Controlling the course of nucleophilic additions to ortho-substituted (η6-anisole)tricarbonyl-chromium complexes: Dienol ether formation versus tele-substitution, H. G. Schmalz, K. Schellhaas, Angew. Chem. Int. Ed., 1996, 35 (18), 2146. 10.1002/anie.199621461

[212] Radical Additions to (η6‐Arene)(tricarbonyl)‐chromium Complexes: Diastereoselective Synthesis of Hydrophenalene and Hydrobenzindene Derivatives by Samarium(II) Iodide Induced Cyclization, H. G. Schmalz, S. Siegel, J. W. Bats, Angew. Chem. Int. Ed., 1995, 34 (21), 2383. 10.1002/anie.199523831

[213] On the enantioselective deprotonation/silylation of prochiral mono- and 1,2-dimethoxybenzene-Cr(CO)3 derivatives, H. G. Schmalz, K. Schellhaas, Tetrahedron Lett., 1995, 36 (31), 5515. 10.1016/0040-4039(95)01077-U

[214] tele-Substitution as the major pathway in intermolecular nucleophilic addition/protonation reactions of ortho-alkylated η6-anisole-Cr(CO)3 derivatives, H. G. Schmalz, K. Schellhaas, Tetrahedron Lett., 1995, 36 (31), 5511. 10.1016/0040-4039(95)01076-T

[215] Diastereoselective transformation of chiral η6-Arene-Cr(CO)3 complexes: Enantioselective synthesis of functionalized hydronaphthalene derivatives related to the seco-pseudopterosins, H. G. Schmalz, A. Majdalani, T. Geller, J. Hollander, J. W. Bats, Tetrahedron Lett., 1995, 36 (27), 4777. 10.1016/0040-4039(95)00887-I

[216] Catalytic Ring‐Closing Metathesis: A New, Powerful Technique for Carbon–Carbon Coupling in Organic Synthesis, H. G. Schmalz, Angew. Chem. Int. Ed., 1995, 34 (17), 1833. 10.1002/anie.199518331

[217] Chemie in Deutschland ‐ Raus aus der Defensive, C. Bolm, B. Frauendorf, A. Griesbeck, U. Kliem, A. Kretschmer, H. C. Militzer, G. Muller, H. Perry, H. J. Rosenkranz, H. G. Schmalz, W. Schnick, A. D. Schluter, R. Stadler, S. Waffenschmidt, Nachr. Chem. Tech. Lab., 1995, 43 (9), 942. 10.1002/nadc.19950430909

[218] Chiral η6-arene-Cr(CO)3 complexes as synthetic building blocks: An enantio- and diastereoselective approach to substituted hydrophenalenes related to helioporin E and pseudopterosin G, H. G. Schmalz, A. Schwarz, G. Durner, Tetrahedron Lett., 1994, 35 (37), 6861. 10.1016/0040-4039(94)85024-0

[219] An approach to chiral η4-butadiene-Fe(CO)3 complexes via diastereoselective complexation of nonracemic 2-alkoxy-4-vinyl-2,5-dihydrofuran derivatives, H. G. Schmalz, E. Hessler, J. W. Bats, G. Durner, Tetrahedron Lett., 1994, 35 (26), 4543. 10.1016/s0040-4039(00)60723-2

[220] The Total Synthesis of cis‐7,8‐Dihydroxy‐11,12‐dehydrocalamenene by Regio‐ and Diastereo‐selective Alkylation of Chiral η6‐Arenetricarbonylchromium Complexes: An Unexpected Case of Nucleophilic Aromatic tele‐Substitution with Methoxide as a Leaving Group, H. G. Schmalz, M. Arnold, J. Hollander, J. W. Bats, Angew. Chem. Int. Ed., 1994, 33 (1), 109. 10.1002/anie.199401091

[221] Chromium Carbene Complexes in Organic Synthesis: Recent Developments and Perspectives, H. G. Schmalz, Angew. Chem. Int. Ed., 1994, 33 (3), 303. 10.1002/anie.199403031

[222] Enantioselektive Heck‐Reaktionen, H. G. Schmalz, Nachr. Chem. Tech. Lab., 1994, 42 (3), 270. 10.1002/nadc.19940420310

[223] Pd‐katalysierte Synthesen Vitamin‐D‐aktiver Verbindungen, H. G. Schmalz, Nachr. Chem. Tech. Lab., 1994, 42 (4), 394. 10.1002/nadc.19940420416

[224] Zr‐katalysierte Carbomagnesierungen von Alkenen, H. G. Schmalz, Nachr. Chem. Tech. Lab., 1994, 42 (7-8), 724. 10.1002/nadc.19940420715

[225] Eisenvermittelte Totalsynthese von Ikarugamycin, H. G. Schmalz, Nachr. Chem. Tech. Lab., 1994, 42 (10), 1016. 10.1002/nadc.19940421013

[226] Intramolekulare Alkoxypalladierungen, H. G. Schmalz, Nachr. Chem. Tech. Lab., 1994, 42 (12), 1267. 10.1002/nadc.19940421213

[227] Chiral η4-butadiene-Fe(CO)3 complexes for organic synthesis: Reactions of (η4-2-alkoxy-4-vinyl-2,5-dihydrofuran)-Fe(CO)3 derivatives, E. Hessler, H. G. Schmalz, G. Durner, Tetrahedron Lett., 1994, 35 (26), 4547. 10.1016/s0040-4039(00)60724-4

[228] Total synthesis of (1S,4S)-7,8-dihydroxycalamenene via benzylic alkylation of η6-arene-Cr(CO)3 complexes, H. G. Schmalz, J. Hollander, M. Arnold, G. Durner, Tetrahedron Lett., 1993, 34 (39), 6259. 10.1016/s0040-4039(00)73725-7

[229] Diastereoselective Complexation of Temporarily Chirally Modified Ligands: Enantioselective Preparation and Configurational Assignment of Synthetically Valuable η6‐Tricarbonylchromium‐1‐tetralone Derivatives, H. G. Schmalz, B. Millies, J. W. Bats, G. Durner, Angew. Chem. Int. Ed., 1992, 31 (5), 631. 10.1002/anie.199206311

[230] Totalsynthese des Pseudoguaianolids (+)‐Confertin, G. Quinkert, H. G. Schmalz, E. Walzer, S. Gross, T. Kowalczykprzewloka, C. Schierloh, G. Durner, J. W. Bats, H. Kessler, Liebigs Ann. Chem., 1988,  (4), 283. 10.1002/jlac.198819880402

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